Liverpool vs. Real Madrid Picks and Predictions: Two UCL Goliaths Battle at Anfield

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Mo Salah and Liverpool host Real Madrid today in the UEFA Champions League - Liverpool Real Madrid Picks

Two of the best teams in all of Europe meet in the most prestigious tournament in the League Phase portion of those contest. Liverpool hosts Real Madrid, as both are looking to go far in this competition. Through three matches, Real Madrid is one of five teams that have yet to lose, winning all of their matches and earning nine points. As for Liverpool, they have two wins but lost on the road to Galatasaray to add a blemish on their UCL record. Can they turn it around at home today? Let’s find out with our favorite picks.

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Liverpool vs. Real Madrid UEFA Champions League Betting Insights

Liverpool were off to a high flying start this season. They won eight straight to start the year in all competitions, including a UCL win over Atletico Madrid when they came to town. However, they were skating by, and it eventually caught up with them. They lost to Galatasaray on the road, and followed it with EPL losses to Chelsea and Manchester United. Liverpool beat Frankfurt in their last Champions League match, but dropped one to Brentford in their domestic league and to Crystal Palace both in the EPL and the Carabao Cup.

Now Real Madrid comes to town, and they are playing as well as anyone on the continent. The visitors have won 13 matches so far this competition season with just one loss and zero draws. Their lone defeat came to Atletico Madrid on the road in La Liga play, losing 5-2 in the Madrid derby. But they are 10-0-0 otherwise in league play, and 3-0-0 in the UCL. Will they keep it going today on the road?

Matchup Information – Liverpool vs. Real Madrid – November 4

  • Venue & Location: Anfield (Liverpool, England)
  • Date: Tuesday, November 4, 2025
  • Kick Off: 3:00 p.m. Eastern
  • Broadcast: Paramount +

Liverpool vs. Real Madrid Betting Odds

Odds are courtesy of our friends at BetOnline, as of November 4, 2025, at 9:51 a.m. eastern. Sign up today with Promo Code BNBOL55 for a 55% deposit bonus, and start betting at the sportsbook with the most competitive odds in the industry, and a wide variety of unique markets not offered anywhere else.

Moneyline

  • Liverpool +139
  • Draw +289
  • Real Madrid +178

Draw No Bet

  • Liverpool -124
  • Real Madrid +104

Total

  • Over 3.5 (+101)
  • Under 3.5 (-121)

Liverpool vs. Real Madrid UEFA Champions League Picks

Trent Alexander-Arnold faces his former club tonight in the UCL - Liverpool Real Madrid Picks

Trent Alexander-Arnold faces his former club tonight in the UCL

Best Bet: Real Madrid Draw No Bet (+104) BetOnline

Real Madrid are simply in much better form right now. For plus money, taking them on the draw no bet line is as close to an auto-bet as you can get with me. They have shutout three of their last four opponents, only conceding to Barcelona in El Clásico, but they still found a way to win. In three UCL matches, they have given up just one goal (to Marseille in their opener) while shutting out Juventus in their most recent contest.

Sure, Liverpool are coming off a 2-0 shutout of Aston Villa at home, but what have they done this season against top clubs? They beat Arsenal at home on a 83′ minute free kick, they beat Atletico Madrid with a stoppage time winner by a score of 3-2, after going up 2-0 just six minutes into the match. They lost to Chelsea, they lost to Manchester United, and they’ve actually lost to Crystal Palace twice already. Point being, they aren’t as good as they once were.

Real Madrid have won six straight since their loss, outscoring their opponents 16-2 in the process. Excluding their five goal loss in the Derby, Real Madrid have given up just six goals in their other 13 matches. That’s less than half a goal every time they take the field. I trust this Spanish back line to be rock solid on the road against a team who is coming back down to Earth, and who have been exposed against top competition this year.

Prediction: Real Madrid Wins 2-1 (+1000)

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