Inter Miami vs. Nashville SC Picks and Predictions: Round One of the MLS Playoffs

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Luis Suarez has 10 goals and 11 assists for Inter Miami this year - Inter Miami Nashville SC Picks

The MLS regular season is behind us, the Wild Card round is over, it’s time for the real deal. Two of the best in the Eastern Conference go head to head tonight to kick things off, as No. 3 Inter Miami hosts No. 6 Nashville SC. We’ve dug into our favorite picks in this 90 minute match, but first we need to familiarize ourselves with the format of the MLS Playoffs.

We are down to eight teams from both conferences. In Round One, teams are playing a best of three series, in a home-away-home format. These games will only see 90 minutes, and if still tied at the end of regulation, they will go straight into a penalty kick shootout. A winner must be decided. And there is no aggregate score. If Team A wins 5-0 the first match, and Team B wins 1-1 on PKs in the second match, the series is still tied 1-1 overall going into that final contest. First to win two matches advances to the conference semifinals. Easy enough!

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Inter Miami vs. Nashville SC Betting Insights

We saw two head to head matches between these teams, and one was actually less than a week ago. Back in July, Inter Miami beat Nashville SC when they came to town, winning 2-1. However, last Saturday to end the season, Inter Miami beat them again, this time at GEODIS Park in Nashville. Plus, this one was much uglier, with the visitors winning 5-2. Nashville went into the locker room up 2-1 thanks to two goals in the 43′ minute and in stoppage time. But Miami responded with an equalizer and a go-ahead goal just four minutes apart in the 63′ and 67′, followed by two more to seal the deal in the 80′ and beyond.

Inter Miami have won the last five head to head matches against Nashville, and are unbeaten in the last nine contests, with six outright wins. Nashville’s last victory against Inter Miami was in 2023, with their last win in Miami coming back in 2022. Do they finally figure things out and break through tonight?

Matchup Information – Inter Miami vs. Nashville SC – October 24

  • Venue & Location: Chase Stadium (Fort Lauderdale, FL)
  • Date: Friday, October 24, 2025
  • Kick Off: 8:00 p.m. Eastern
  • Broadcast: FS1

Inter Miami vs. Nashville Betting Odds

Odds are courtesy of our friends at BetOnline, as of October 24, 2025, at 2:42 p.m. eastern. Sign up today with Promo Code BNBOL55 for a 55% deposit bonus, and start betting at the sportsbook with the most competitive odds in the industry, and a wide variety of unique markets not offered anywhere else.

Moneyline

  • Inter Miami -162
  • Draw +383
  • Nashville SC +375

Spread

  • Inter Miami -1 (-105)
  • Nashville SC +1 (-115)

Total

  • Over 3.5 (-112)
  • Under 3.5 (-108)

Look, it’s very hard to beat a team three times in a single season, and Inter Miami will need to beat Nashville four times this season in order to advance. All the pressure is on the hosts as huge favorites. The club from Music City will know they have to steal at least one of these road matches to move on, so they might as well do it the first chance they have.

Inter Miami vs. Nashville SC MLS Picks and Predictions

Hany Muktar and Nashville need to show up on the road - Inter Miami Nashville SC Picks

Hany Muktar and Nashville need to show up on the road

Best Bet: Nashville SC +1 (-115) BetOnline

All we gotta do is hold on for 90 minutes. Sure, Inter Miami is the highest scoring offense in the league, netting over 80 goals this season, but Nashville can hold their own. Not only are they a top 10 defense in terms of goals allowed, they are also top 10 in goals scored as well (ranking No. 4 in the Eastern Conference). They have all the intangibles on their side, and we have some push potential if they can keep it within a goal, just like they did last time in Fort Lauderdale.

You might be wondering… “Didn’t Miami just score five against Nashville on the road? Won’t they blow them out even more at home?… The answer… of course that’s a possibility. However, Music City is back in the playoffs after missing the postseason last year. They were blanked in both matches against Orlando City, losing 1-0 in both games last time they competed in the postseason. They will be very eager to turn things around, and I think Miami could be caught sleeping in this first postseason contest.

The Nashville back line will need to hold strong, but if they can limit the hosts to just one goal, I think we have a chance at winning this bet.

Prediction: 1-1 Draw (+850)

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