The 49ers come into this week looking for their fourth straight win and this week they’ll host this year’s #1 overall pick; Cam Ward. The Titans are fresh off their second win of the year and looking for their third. Let’s jump right into it.
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Game Information
Matchup Information
- Location: Levi Stadium; Santa Clara, California
- Date: Sunday, December 14th, 2025
- Kickoff: 4:25 PM EST
Quarterback Matchup
- Tennessee Titans: Cam Ward (2024 – n/a)
- San Francisco 49ers: Brock Purdy (6-9; 2024 – 257.6 YPG | 20 TD | 12 INT)
Betting Odds
Odds via Lucky Rebel, an industry leader in the sports betting world.
Analysis & Breakdown
Titan Up
Last week we watched the very first matchup between two of the game’s most promising young QBs, Cam Ward and Shadeur Sanders. Snow was falling, the two QBs were slingin’ and both offenses were stacking points. Ward completed just 50% of his passes for 117 yards but did throw 2 touchdowns in the process.
It was the Titans run game that came alive last week, against one of the league’s best run defenses too. Tony Pollard had his best game of the year, finishing with 161 yards on the ground, 2 touchdowns and averaging 6.7 yards per carry. Pollard was on a different planet and my fantasy team thanks him for it.
The defense was just as bad last week as it’s been all year. The Titans let Shadeur throw for 364 yards and 3 touchdown passes but did force 1 interception. The defense gave up 412 yards of total offense, 29 points and almost let the Browns come back and play spoiler.
It’s been the story of their season, the Titans defense is bad. The defense ranks 29th in points allowed, 26th in opponent redzone efficiency, 23rd in opponent pass yards and 27th in opponent yards per play.
The offense hasn’t been much better. They rank 31st in points scored, 31st in pass yards, 31st in rush yards, 32nd in yards per play and in first downs generated. It’s been a tough watch in Tennessee and it’s why we’re seeing such a big spread this week.
The Bay Area Bullies
The Niners have won four games in a row and sit just one game back of the division lead. This with all the injuries they’ve had, Brock Purdy missing a ton of game, George Kittle and Ricky Pearsall both missing a big chunk of games. The team’s still without their All-Pros on defense; both Fred Warner and Nick Bosa out for the year.
It hasn’t stopped the 49ers from playing great football. The team’s defense ranks 8th in points allowed, 12th in opponent rush yards, 13th in opponent redzone efficiency and this is all while getting virtually zero pressure on opposing QBs.
San Francisco ranks dead last in sacks this year, bottom five in pressure rate and tackles for a loss. The defense adopted a bend but don’t break mentality and it’s lead to a 9-4 record through 14 weeks.
The offense has been good, despite not knowing who’s going to be on the field for any particular Sunday. The team’s missed significant time from Purdy, Pearsall, Kittle and this week it’s McCaffrey back on the injury report.
McCaffrey’s played in all 13 of the 49ers games this year and he’s looked amazing. He’s averaging 127.3 yards from scrimmage per game, he’s got 13 touchdowns and he’s the 49ers leading receiver. That’s not a typo, McCaffrey is the 49ers leading receiver.
McCaffrey’s got 85 receptions for 806 yards and could eclipse 1,000 yards receiving for the second time in his career. He’s one of just five RBs to accomplish that feat, one of just three to record simultaneous 1,000/1,000 yyard seasons. He would be the only RB in NFL history to do it twice.
That being said, he popped up on the injury report with a back issue on Saturday and that’s never a good sign.
Sunday’s Best Bets
Brian Robinson o29.5 Rushing Yards (-114) | Lucky Rebel
This one might feel weird, but with this 12.5-point spread, I’m looking to Brian Robinson Jr. to have a significant role this week. Reports are that McCaffrey will be good to go for tomorrow’s matchup, despite being downgraded to questionable.
I like this more if McCaffrey plays. The Titans have the 18th ranked run defense and allow opponents to average 4.6 yards per carry. Robinson’s seen 8+ carries in three of the team’s last four games and we could see this game get out of hand.
The 49ers should be playing with a lead in this one, giving plenty of opportunity for some late game carries and clock milking. Tennessee ranks 25th in time of possession and they just haven’t been able to keep the offense on the field.
Robinson should see 8-10 carries in this one and with him averaging 4.5 yards per carry; I’m confident he gets us over this line.
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