Titans vs. Broncos Picks: Week 1 Insights and Predictions

Sean Payton has lost both home openers as the Broncos head coach - Titans Broncos Picks

We have a full slate of NFL action this Sunday to kick off Week 1 of the season. Things really get started Thursday as the defending Super Bowl Champion Philadelphia Eagles host their NFC East rival, the Dallas Cowboys to open things up, and we also get an AFC West battle in Sao Paulo as the Kansas City Chiefs take on the Los Angeles Chargers in Brazil. The first NFL weekend is always exciting, but we are going to a matchup that might be a bit one sided. I’m headed to Mile High Stadium as the Denver Broncos take on the Tennessee Titans. Let’s get into our favorite picks.

Check out the latest odds at the best online sportsbooks. Plus, take some time to check out our NFL Divisional Previews below.

Tennessee Titans vs. Denver Broncos NFL Betting Insights

Cam Ward leads the Titans against Denver on the road to start his NFL career

This is by far the biggest spread on the NFL betting board for Week 1 (aside from the Eagles vs. Cowboys which has ticked up to nine on BetOnline), and I’m sure the Broncos will be an extremely popular survivor pick. Who wouldn’t want to fade a rookie QB on the road in his first NFL start?

Sean Payton has lost both of his home openers as the Broncos head coach, but I definitely think Denver found their guy in Bo Nix. He ranked No. 12 in passing yards last season with 3,775, was No. 6 in passing touchdowns with 29, but was a little interception-friendly, throwing 12 throughout the year. Nix slipped in to the top 10 in rushing yards from a quarterback, running for 430 throughout the season and adding four rushing touchdowns as well.

Adding J.K Dobbins gives Nix some help in the backfield, and signing Evan Engram at TE gives him another pass catching weapon. But we also get to see the No. 1 overall draft pick begin his career with the Titans.

Tennessee is pretty much rebuilding, but does have some compelling skill players. Obviously they are headlined by No. 1 overall draft pick, Cam Ward. Tony Pollard will take the lead role in the backfield as Tyjae Spears will miss the first several games with an injury, and Calvin Ridley returns to lead a pass catching corps paired with Tyler Lockett out wide. Tennessee’s defense is also enticing, which could make this game more interesting than some might think.

Matchup Information – Titans vs. Broncos

Venue & Location: Empower Field at Mile High (Denver, CO)
Date: Sunday, September 7, 2025
Kick Off: 4:05 p.m. Eastern
Broadcast: FOX

Titans vs. Broncos Betting Odds – September 7

Odds are courtesy of BetOnline, one of our favorite online sportsbooks as of September 3, 2025, at 5:51 p.m. eastern. Sign up today with Promo Code FREE250 for a 50% deposit bonus up to $250 as well as 100 Free Spins at the online casino.

Spread

Titans +9 (-114)
Broncos -9 (-106)

Moneyline

Titans +358
Broncos -460

Total

Over 42.5 (-115)
Under 42.5 (-105)

I’m not simply fading a rookie QB on the road in his first ever start, but that is exactly where my money is going in this matchup. Two out of three rookie quarterbacks lost their opener last season (Jayden Daniels at Tampa Bay and Nix @ Seattle), and the only reason Caleb Williams pulled out a win was because of his defense (and Will Levis sucks). Plus, Williams was at Solider Field.

The last rookie QB to win their NFL debut on the road was Sam Darnold of the New York Jets in 2018, and historically speaking, it doesn’t happen often. Denver’s defense is still top notch, and I see Tennessee struggling to score some points.

Tennessee Titans vs. Denver Broncos Picks and Predictions

Pat Surtain leads a loaded Denver defense into the 2025 NFL season

Titans vs. Broncos NFL Prediction: Broncos Win & Cover, Under 42.5

Best Bet: Titans Team Total Under 16.5 (-115) BetOnline

Now, I do think Denver wins by double digits. But part of me is having pause backing them to do so, just because I would like to take the Broncos’ offense out of the equation. Sure, Nix could throw a pick six or special teams could give up some points (immediately knocks on wood), but I do not see this defense allowing more than two touchdowns, if that.

Denver ranked No. 3 overall last season in points allowed per game, giving up just 19 per contest. At Mile High, they were the best scoring defense in the entire league, allowing just 14.9 points at home. They were No. 2 in the NFL in yards per play allowed at home, giving up just 4.8, and led the league in opponent punts per offensive score and touchdowns allowed per game. At home, Denver forced their visitors to punt 1.9 times in between each score (not touchdown), and only gave up 1.5 TDs per contest.

This defense is elite, they will certainly carry this team all season long if Nix falls into a sophomore slump, and I see them making Cam Ward’s life a living hell in Denver this Sunday. Obviously I would much rather bet under 17.5 or even 17 for some push potential, but the juice isn’t worth the squeeze. Books want -155 for 17 plus the hook, and I’m simply willing to bet they don’t find the end zone more than once. Give me the Titans team total under this Sunday.

Still Didn’t Get Your NFL Fix?

Here at Betting News, we offer Free Expert Picks for every major sports league. We also host daily streams on our Twitch Channel with our best bets, as well as sweat out games on Playback! Be sure to tune into everything we have going on at our Youtube, TikTok, and X pages as well.

Get FREE Picks and Props Weekly

Sign up for
THE WEEKENDER NEWSLETTER

Get FREE Picks

Tennessee Titans vs. Denver Broncos Picks and Predictions: How Will Ward Perform on the Road?