The Bills look incredible and the Saints look incredibly bad. Let’s jump right into this matchup between David and Goliath.
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Game Information
Matchup Information
- Location: Highmark Stadium; Orchard Park, New York
- Date: Sunday, September 28th, 2025
- Kickoff: 1:00 PM EST
Quarterback Matchup
- New Orleans Saints: Spencer Rattler (0-6; 2024 – 197.0 YPG | 3 TD | 5 INT)
- Buffalo Bills: Josh Allen (13-4; 2024 – 219.5 YPG | 28 TD | 6 INT)
Betting Odds
Odds via BetOnline, an industry leader in the sports betting world.
Analysis & Breakdown
How Bad are They?
The Saints are pretty bad. Through three weeks of football, they’re 0-3 and Rattler’s moved to 0-9 as a starter in the NFL. This team didn’t have any expectations entering the season and to be fair, looked okay before Week 3. Then in Week 3, the wheels completely fell off. The Saints walked into their matchup with the Seahawks and next thing you know; the Saints are down 21-0 in the first quarter.
Special teams was a huge problem, the defense was an even bigger problem and even the progression from Spencer Rattler hasn’t helped the situation. Rattler threw for 218 yards against the Seahawks, completed 71% of his passes, threw one touchdown and his first interception of the year. Rattler’s completing 67% of his passes on the year, averaging 213 yards per game and has now thrown four touchdowns.
This week the Saints will travel from one coast to the other; going from Seattle to Buffalo for their matchup with the Bills. Travel’s tough, back to back road games are tough; but going across the country to face a Bills team playing in their second straight home game, even tougher.
Super Bowl or Bust
Through just three weeks of the 2025 NFL Season, the Bills have scored 102 points, recorded 1,260 total yards, scored 11 total touchdowns and have scored 30+ points in all three games. Buffalo started the season with one of the craziest Week 1 comebacks we’ve ever seen. The Bills entered the fourth quarter down 15 points and proceeded to outscore the Ravens 22-6 in the final frame. Matt Prater walked it off with a 32-yard game winning field goal and the Bills have been cruising ever since.
In back to back divisional games, the Bills put up 30 points on the Jets and 31 on the Miami Dolphins; outscoring both teams by a combined 30 points. Josh Allen’s looked great, averaging 251.7 pass yards per game, throwing five touchdowns and no interceptions. He’s added two more touchdowns on the ground and has yet to turn the ball over.
James Cook has looked unstoppable out of the backfield, recording 355 total yards from scrimmage with four touchdowns through just three games. Keon Coleman’s coming into his own as a WR1 for the Bills, leading the team in target share and averaging 52.7 receiving yards per game.
Sunday’s Best Bets
Keon Coleman o43.5 Receiving Yards (-110)
Keon Coleman leads the Bills in target share but he’s coming off back to back duds. Against the Jets, he was matched up with one of the top corners in the league, Sauce Gardner, so it’s no surprise to see the decline in targets. In Week 3 against the Dolphins, we saw Khalil Shakir make a splash against a Dolphins team that struggled against slot receivers. This week it’s the opposite, the Saint have given up 75% of receiver production to receivers lined up out wide.
In Week 3 we saw the Saints get torched by Jaxson Smith-Njigba for five catches and 96 yards; despite playing just 49% of the snaps due to the blowout. This week it’s Coleman’s turn.
Coleman’s taking 88% of snaps out wide and will matchup with a Saints’ secondary graded in the bottom 10 so far this year. The Saint pass rush ranks bottom three this year and if you give Josh Allen time in the pocket, bad things are going to happen.
Juwan Johnson o46.5 Receiving Yards (-110)
The Saints enter this game as a 16.5-point dog this week. Vegas has already deemed this game a blowout and it’s why I’m expecting Spencer Rattler to be throwing the ball. So far this year, Rattler’s averaging 39.7 pass attempts per game and he’s completing 67% of his passes. His two favorite targets have been Chris Olave (31.9%) and Juwan Johnson (24.1%).
Johnson sits second among tight ends this year in targets, fifth in receiving yards, third in yards after the catch and third in red zone targets. He’s become a huge part of this offense and Spencer Rattler has developed quite the connection with his tight end. The Bills secondary and coverage group have been good this year, but have yet to play a high usage tight end.
Johnson’s a former wide receiver turned tight end and you can see it with his play on the field. Look for him to have an impact this week in Buffalo.
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