NFL Week 1 Staff Picks: Best Bets & Props from our NFL Experts

And here we go again…

The NFL Season is Back! The schedules are set, the preseason is done. Now, it is time to play some Football!

Below, our Team here at Betting News is going to give their BEST BETS for Week 1 of the 2025 NFL Season. Whether it is a Spread, Moneyline, Total or Player Prop, this is your go to article every week for our team’s favorite bets on the gridiron.

Now let’s dive in to the Betting News Squad Best Bets for Week 1 of the NFL Season!

All Odds available at BetOnline, the industry leader in the Sports betting Market.

Daniel Collins’ Week 1 NFL Best Bet

Rams -3 (-115) BetOnline

I am pretty low on this Texans team this season. C.J. Stroud coming off his sophomore slump season last year should bounce back this season, sure,  but the offensive line in Houston could end up being a bottom 5 unit in the league. That could be a recipe for disaster in more ways than one and could be on display in Week 1.

On the other side, the Rams are one of my favorite teams in the NFC to make some noise, especially with their possibly lethal offense.

In Lala Land, give me the more complete team to cover at home.

Chef T’s Week 1 NFL Best Bet

Brian Thomas Jr Touchdown (+130) BetOnline

Brian Thomas Jr. stands out as Jacksonville’s top red-zone receiving threat, commanding a 27% target share inside the 20 — elite usage for a rookie WR1.

Carolina’s secondary was one of the worst in the league against WR1 touchdowns last year, ranking 31st. At +130, Thomas pairs heavy volume with a dream matchup, making him the most reliable Jags receiver bet to score.

Nate Hornung’s NFL Week 1 Best Bet

Jayden Higgins (HOU) Over 26.5 Receiving Yards (-115) and Anytime TD (+350) BetOnline

The Texans are going to have to throw the ball. Nick Chubb might not be as impactful at RB, and regardless, Houston will want to use Stroud’s arm. Obviously Nico Collins is the go-to guy, but with no Tank Dell and Christian Kirk being ruled out as well, there are targets to go around.

Enter Jayden Higgins. A 6’4″ monster wideout, already listed as the WR3 who will now get WR2 reps in this contest. The man had over 2,000 receiving yards his past two years at Iowa State with 15 total TDs. In a depleted receiving corps, Higgins is ready to make his mark.

For a full breakdown, check out my Texans vs. Rams article.

Colby Marchio’s NFL Week 1 Best Bet

Jets +3 (-110) BetOnline

As a proud ticket holder of Jets over 5.5 wins this season, it only feels right to kick off Week 1 rooting for them to do the bare minimum: cover +3.

I’ve been sold on this team ever since I read the words “hard ass” describing new head coach Aaron Glenn. He brings a fresh dynamic and attitude to this organization. On top of that, I’m giving Justin Fields one last chance.

He flashed in Pittsburgh during his early starts, and if the Jets can run an offense similar to what the Commanders are doing with Jayden Daniels, this group could actually be fun.

John Hyslop’s NFL Week 1 Best Bet

Jameson Williams o3.5 Receptions (-108) BetOnline

We need to start the season with a win, and damnit, this legitimately has no shot of losing.

Jameson Williams isn’t just a fly route guy anymore; he’s running everything. He’ll have this by halftime.

Feels easy.

Varun Sharma’s NFL Week 1 Best Bet

Chubba Hubbard o9.5 Receiving Yards (-110) BetOnline

Last year Chubba Hubbard finished third on this team in receptions, lead the team in yards from scrimmage and touchdowns. Hubbard enters his fifth year in the league fresh off his first ever 1,000 yard season, first ever 10+ touchdown season and 40+ reception season.

Last year, Hubbard finished with four or more receptions in 9 of his 15 games, but averaged just 3.9 yards per catch. The Panthers offense was ranked in the bottom five last year and their wide receiver room has only gotten thinner.

Brad Blakemore’s NFL Week 1 Best Bet

Trevor Lawrence o1.5 Pass TDs (-115) BetOnline

Trevor Lawrence has a new pass happy coach. Two game breaking wide receivers.

And he faces the Carolina Panthers, who allowed an average of two touchdowns against last season. Yeah gimmie TLaw o1.5 passing touchdowns at -115 all day.

Danny Burke’s NFL Week 1 Best Bet

New York Giants +6 (-112) BetOnline

Everyone seems to be jumping on the Commanders hype train, expecting them to be even more dominant than last season – which was a surprise in itself. But teams now have a full year of tape on Jayden Daniels and this offensive scheme, which should lead to some regression.

This feels like too many points in a division matchup to open the season, especially with the Giants having all offseason to prepare and a competent (enough) quarterback available.

Kate Constable’s NFL Week 1 Best Bet

Dolphins +1.5 (-110) BetOnline

I’m really low on the Dolphins for the season. Like I think they could be one of the worst teams in the league type of bad. But Miami always start off hot.

They’ve won all three Week 1 games with Mike McDaniel as their coach and I like their rebuilt offensive line while they’re healthy. I also don’t trust Daniel Jones against pressure. I’ll take the slight road dog. 

Adam Kaufman’s NFL Week 1 Best Bet

Bengals -5.5 (-120) BetOnline

Joe Burrow stinks in Cleveland. Myles Garrett’s been a nightmare for him. Cincinnati’s defense stinks out loud. Zac Taylor’s 1-9 straight up in Weeks 1 & 2, with that only win coming in OT four years ago. 

Don’t care. Don’t care. Don’t care. Don’t care.

Cincy’s coming off back-to-back underwhelming seasons. If the Bengals want to be taken seriously as a playoff contender or better, that starts immediately against an inferior Browns team with a 40-year-old QB.

Week 1’s never a must-win, but it’s an opportunity to make a statement. Burrow and that elite offense will be ready.

Tristan Vieira’s NFL Week 1 Best Bet

Colts -1.5 (-110) BetOnline

Danny Dimez debut at home, I expect him to show up and show out to prove the doubters wrong. I believe his time spent with Kevin O ‘Connell last season made an impact.

The Dolphins have all hands on deck for the first time in a long time and still find themselves as underdogs on the road to a debut QB & a young Colts team. The public is all over the Dolphins yet the line isn’t budging, give me Danny Dimes to cover.

Sukh Brar’s NFL Week 1 Best Bet

Carolina Panthers +3.5 (-110) BetOnline

The Carolina Panthers are going to surprise people this season in my opinion. This team has weapons and potential. Multiple talented first round receivers and two solid running backs. 

What’s my opinion worth? Not a lot. However, if you trust me then I think their surprising season starts in Week one as road dogs.

Thanks for stopping by & enjoy NFL Week 1!

You can also check out more free picks & analysis from every NFL Week 1 Game right here!

Also, get the best odds & all the up to date lines right here at Betting News!

You can  follow us at Betting News on X/Twitter for all of our sports betting content. You can also watch us on the Betting News Network multiple times a day, streaming on Twitch & Youtube every day as well!

Also subscribe to our weekly newsletter!

Looking for a great promo for a new sportsbooks? Check out all the various sign-up bonuses & reviews we have for numerous sportsbook, available everywhere!