Los Angeles Chargers vs. Detroit Lions Picks and Predictions (7/31): Football Season Officially Begins

Jim Harbaugh leads the Chargers in his second season as head coach - Chargers Lions Picks

The wait is over. It’s been several long months since we last saw some football on our screens, but tonight the NFL returns with the Hall of Fame Game, kicking off the preseason between the Los Angeles Chargers and the Detroit Lions in Canton, Ohio. Our expert’s have been itching to bet some football all offseason, so of course we dove in to this matchup and found our favorite picks for tonight.

Check out the latest odds at the best online sportsbooks. Plus, take some time to check out our NFL Divisional Previews below.

Don’t worry, we’re saving the South for last, should be up next week!

Alright, time to get into tonight’s matchup.

Los Angeles Chargers vs. Detroit Lions: Hall of Fame Game Picks

Dan Campbell leads the Lions into the 2025 Hall of Fame Game - Chargers Lions Picks

Dan Campbell leads the Lions into the 2025 Hall of Fame Game

Matchup Information

  • Venue & Location: Tom Benson Hall of Fame Stadium (Canton, OH)
  • Date: Thursday, July 31, 2025
  • Kick Off: 8:00 p.m. Eastern
  • Broadcast: NBC/Peacock

Chargers vs. Lions Betting Odds – July 31

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Spread

  • Chargers +1.5 (-118)
  • Lions -1.5 (-102)

Moneyline

  • Chargers +101
  • Lions -121

Total

  • Over 34 (-110)
  • Under 34 (-110)

Can I just say… it feels fantastic to be chit chatting about some football. Seeing a total for anything above four really gets me going (I’ve been betting a lot of soccer this offseason), and tonight’s game is just the teaser for what should be another phenomenal NFL season.

However tonight we are likely not going to see very many starters, as Los Angeles has already indicated QB Trey Lance will take over for the offense tonight. I would imagine we don’t see Jared Goff or any of the Lions’ skill players as well. But let’s dive in deeper about who might be seeing the field, and how we can go about wagering on this Hall of Fame Game.

Los Angeles Chargers vs. Detroit Lions Picks and Predictions

Trey Lance starts for the Chargers tonight in the Hall of Fame Game - Chargers Lions Picks

Trey Lance starts for the Chargers tonight in the Hall of Fame Game

Chargers vs. Lions NFL Prediction: Lions Win, Under 34

Best Bet: LAC/DET 1H Under 17.5 (-108) BetOnline

I think we see points in this matchup, but I don’t think we see too many early. We obviously are not going to get the top offensive players, and likely won’t see the best of the best on defense either. However my theory is defense takes less rust to shake off, while you need some time to let an offense gel and build a rhythm.

In this game tonight, I’m not sure how much rhythm we will see from these two backup squads.

Trey Lance doesn’t move the needle for me, and Dan Campbell has said we won’t see very many starters. Hendon Hooker will lead the Lions, with Kyle Allen likely getting some reps as well. Despite the first team defenses probably not trotting out their either, I’ll side with a back up defense over a back up offense in the very first game of the season.

Both of these coaches are very defensive minded, and I bet it shows tonight, especially with both teams ranking in the top 10 in points allowed last season.

Give me less than three scores in the first half.

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