Battle in the AFC between two teams that start the season 1-0. The Denver Broncos take a trip to the Midwest, ready to face a Colts’ team with Daniel Jones under center. Let’s jump right into the game.
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Game Information

Matchup Information
- Location: Lucas Oil Stadium; Indianapolis, Indiana
- Date: Sunday, September 14th, 2025
- Kickoff: 4:05 PM EST
Quarterback Matchup
- Denver Broncos: Bo Nix (10-7; 2024 – 222.1 YPG | 29 TD | 12 INT)
- Indianapolis Colts: Daniel Jones (2-8; 2024 – 207.0 YPG | 8 TD | 7 INT)
Betting Odds
Odds via BetOnline, an industry leader in the sports betting world.
Analysis & Breakdown

Danny Dimes
Daniel Jones asked for his release in November of 2024, the Giants obliged and he finished the season with Minnesota, backing up Sam Darnold. During the off-season, Jones signed a 1-year deal with the Indianapolis Colts and the coaching staff made it clear from the jump; QB1 is up for grabs. Jones beat out Anthony Richardson during training camp and entered Week 1 as the team’s top quarterback.
With so many questions surrounding Head Coach Shane Steichen’s decision, Jones came out and absolutely went crazy. Jones threw the ball 29 times, completed 76% of his passes and threw for 272 yards and one touchdown. The Colts’ new quarterback added two touchdowns on the ground, 26 yards rushing and finished the game with no turnovers. The Colts won the game 33-8 and start the season 1-0 for the first time since 2013, back when Andrew Luck was still under center.
Outside of Jones, this Colts’ defense looked elite in Week 1. Indianapolis allowed just 211 total yards in the opener, just 114 yards threw the air and did a great job of keeping Tyreek Hill and Jaylen Waddle in check. This week, against this young Broncos quarterback, look for Indianapolis to come out and shut down this air attack.
Big Dreams in Mile High
This Denver Broncos team is coming into this season with more hype than we’re used to. Not since Peyton Manning played for the Broncos have they had this type of excitement for the guy under center. Bo Nix had a great rookie year, averaging 222.1 pass yards per game, completed 66% of his passes, threw 29 touchdowns and just 12 interceptions. Denver won 10 games in his rookie year, made the postseason and eventually lost to Buffalo in the AFC Wild Card game. Broncos fans should definitely be excited.
Week 1 wasn’t the prettiest, but they walked away with the win. Denver beat Tennessee 20-12, Bo Nix threw two interceptions and the Broncos struggled to move the ball at times. The team finished with just 317 total yards of offense, 151 of those yards coming on the ground. J.K. Dobbins is now in this Broncos backfield and looked good in his debut. Dobbins finished with 63 yards on 16 carries, averaging 3.9 yards per carry and scoring the team’s lone rushing touchdown.
Rookie RJ Harvey saw just six carries but made the most of his opportunities, totalling 70 yards on the ground with a 50-yard scamper under his belt. Dobbins saw a 53% snap share in Week 1 with Harvey coming in at 29%. I wouldn’t be surprised to see Harvey’s opportunities go up after the way he finished Week 1.
Sunday’s Best Bets
Tyler Warren o41.5 Receiving Yards (-110)

We’re going right back to the Colts’ rookie tight end. Warren saw a 30% target share in Week 1 and the Colts only threw the ball 29 times. He lead the team in targets with both Warren and Michael Pittman Jr. accounting for 59% of the team’s target share.
Usage like that for any rookie is crazy, usage like that for a rookie tight end is something even more rare; Brock Bowers being the most recent example. Last year Bowers finished sixth in the NFL in targets, third in receptions, and eighth in receiving yards; all as a rookie.
It’s only a one game sample size, but Warren saw a 73% snap share in Week 1 but 30% target share. Against a Broncos defense with Patrick Surtain on the outside and Talanoa Hufanga in the safety spot, you’ve got to utilize Warren and the size advantage he brings to the table.
J.K. Dobbins o46.5 Rush Yards (-110)

J.K. Dobbins dominated the backfield touches in Week 1, seeing a 53% snap share and averaging 3.9 yards per carry. He had a 16-yard scamper for six to ice the game for the Broncos, giving them an eight point lead with seven minutes left.
Dobbins finished the game with 18 total touches, 16 rushing attempts and this was in a one-score game. The Colts blew the doors off Miami last week, forcing the Dolphins to go pass heavy, early in the game. The Dolphins called just 10 run plays in their Week 1 beatdown, but the team still averaged 6.5 yards per carry. De’Von Achane only ran the ball seven times, but still finished with 55 yards on the ground; averaging 7.9 yards per carry.
The Broncos and Colts enter this game basically at a pick ’em. Both teams looked good in Week 1, but the Broncos offense sputtered. Look for Denver to pound the ball on the ground and attack this soft front seven of the Colts.
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