We’ve got an inter-conference matchup this week as the Houston Texans host the San Francisco 49ers. Let’s jump right into this one.
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Game Information
Matchup Information
- Location: NRG Stadium; Houston, Texas
- Date: Sunday, October 26th, 2025
- Kickoff: 1:00 PM EST
Quarterback Matchup
- San Francisco 49ers: Mac Jones (2-8; 2024 – 167.2 YPG | 8 TD | 8 INT)
- Houston Texans: C.J. Stroud (10-7; 2024 – 219.2 YPG | 20 TD | 12 INT)
Betting Odds
Odds via BetOnline, an industry leader in the sports betting world.
Analysis & Breakdown
Mac Daddy
Mac Jones is 4-1 as a starter this year for the 49ers, he’s completing 67% of his passes and attempting just under 40 passes per game. Mac’s averaging 280.8 pass yards per game with six touchdowns and four interceptions. Outside of their Week 6 loss to the Buccaneers, Mac and company have looked exceptional.
In the 49ers four wins, Mac’s averaging 264.3 yards per game with six touchdowns and just two interceptions. He’s been sacked six times in these four wins and has a completion rate of 66%. In the one loss to Tampa Bay, Mac threw two interceptions, was sacked six times and the offense looked discombobulated.
San Francisco will be without both Nick Bosa and Fred Warner for the remainder of the season. On the offensive side, it looks like Mac’s going to once again get the start.
Purdy playing this week’s a stretch and Ricky Pearsall looks to miss another week with a PCL injury. Mac Jones and Kendrick Bourne have a built in connection and I’m expecting to see more of that this week in Houston.
Houston, we have SO many problems
The Houston Texans have one of the worst offensive lines I’ve ever seen play football. After two weeks of bad opponents, people forgot how bad Houston looked through the first four weeks of the year. Wins over the Ravens and Titans had people thinking the Texans might have figured it out and you can’t blame them.
Stroud threw for four touchdowns in the win over Baltimore but looked like a completely different QB last week in Seattle. Stroud completed just 47% of his passes last week for 229 yards, one touchdown and one interception. He’s averaging 217.5 pass yards per game this year with nine touchdowns and four interceptions. He’s been sacked 15 times and the Texans offensive line ranks in the bottom 10 for pass blocking grade.
This Texans offense needs to keep their best player on his feet and until they do that you can’t expect them to win a ton of games.
Sunday’s Best Bet
Christian McCaffrey o5.5 Receptions (-110) | BetOnline
Christian McCaffrey currently leads the 49ers in target share, seeing a 25.9% target share and averaging 10 targets per game. He’s cleared this line in every game this year and with all the injuries it’s been just McCaffrey and Kendrick Bourne. George Kittle returned to the field last week but failed to record a single reception.
McCaffrey’s averaging 6.7 receptions per game this year while seeing 9.7 targets per game. He’s actually averaging more receiving yards per game (73.7) than he is on the ground (66.4) and he’s got six total touchdowns; three on the ground and three through the air. He’s the 49ers MVP and you have to think they continue to feed him the ball.
McCaffrey ranks 4th in target rate against the blitz this year and it’s really helped Mac Jones when facing pressure this year. The Texans have one of the best pass rushes in the NFL and Will Anderson Jr. has been an absolute menace and the entire defensive line for the Texans has been causing havoc. With all the injuries on the 49ers side of the ball, I’m expecting them to stick to what’s been working; feeding McCaffrey.
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