The UFC is heading back to the middle east for a massive PPV at UFC 321! The stage has been set with a 14 fight card filled with great match ups and skilled fighters.
MMA fans across the globe will finally see the return of Tom Aspinall who is taking on Cyril Gane for the undisputed Heavyweight title. Aspinall will be making his return after a long year lay off and fans are excited to see him back in action.
The Co – Main event is equally interesting as Mackenzie Dern will be taking on Virna Jandiroba in a rematch. The first time the women fought was an incredible fight, now the stakes have been raised with the strawweight title on the line.
We will see other top prospects such as Umar Numagomedov, Jose Delgado, and Azamat Murzakanov make their returns to the octagon as well. One thing is for certain it is that the card is stacked.
MMA fans across the globe are highly anticipating the Saturday Matinee fight card. On that note fight day is quickly approaching so lets get right into all the odds and predictions of UFC 321!
Article Transparency – UFC Rio Record 9-3, 200-141 overall in 2025*
All betting odds are presented by BetOnline.ag as of 10/22/2025 at 8 a.m.
Check out the odds for the entire card at the best online sportsbooks available in the US.
Main Event: Tom Aspinall (C) vs Cyril Gane Odds – Heavyweight Championship
Aspinall Makes His Return To Take On Cyril Gane For The Undisputed Title
- Age: Tom Aspinall (32) vs Cyril Gane (35)
- Record: Tom Aspinall (15-3) vs Cyril Gane (13-2)
- Last 5: Tom Aspinall 4-1 / Cyril Gane 3-2
- Moneyline: Tom Aspinall (-400) vs Cyril Gane (+300)
- Round Total: 1.5 Total Rounds – Over (-120) / Under (+100)
- Most Likely Method Of Victory: Tom Aspinall By KO/TKO (+100)
Main Event: Tom Aspinall (C) vs Cyril Gane Prediction – Under 1.5 Total Rounds () at Betonline
Co – Main Event: Mackenzie Dern vs Virna Jandiroba Odds – Strawweight Championship
Dern & Jandiroba Will Be Squaring Off For A Rematch With Much Higher Stakes
- Age: Mackenzie Dern (32) vs Virna Jandiroba (27)
- Record: Mackenzie Dern (15-5) vs Virna Jandiroba (22-3)
- Last 5: Mackenzie Dern 3-2 / Virna Jandiroba 5-0
- Moneyline: Mackenzie Dern (-155) vs Virna Jandiroba (+135)
- Round Total: 4.5 Total Rounds – Over (-115) / Under (-105)
- Most Likely Method Of Victory: Mackenzie Dern By Points (+255)
Mackenzie Dern vs Virna Jandiroba Prediction: Mackenzie Dern Wins (-155) at Betonline
Umar Nurmagomedov vs Mario Bautista Odds – Bantamweight
- Age: Umar Nurmagomedov (29) vs Mario Bautista (32)
- Record: Umar Nurmagomedov (18-1) vs Mario Bautista (16-2)
- Last 5: Umar Nurmagomedov 4-1 / Mario Bautista 5-0
- Moneyline: Umar Nurmagomedov (-625) vs Mario Bautista (+475)
- Round Total: 2.5 Total Rounds – Over (-250) / Under (+207)
- Most Likely Method Of Victory: Umar Nurmagomedov By Points (-175)
Umar Nurmagomedov vs Mario Bautista Prediction: Umar Nurmagomedov Wins (-625) at Betonline
Alexander Volkov vs Jailton Almeida Odds – Heavyweight
- Age: Alexander Volkov (37) vs Jailton Almeida (34)
- Record: Alexander Volkov (36-11) vs Jailton Almeida (22-3)
- Last 5: Alexander Volkov 4-1 / Jailton Almeida 4-1
- Moneyline: Alexander Volkov (+170) vs Jailton Almeida (-200)
- Round Total: 1.5 Total Rounds – Over (-118) / Under (-102)
- Most Likely Method Of Victory: Jailton Almeida By Submission (+140)
Alexander Volkov vs Jailton Almeida Prediction: Alexander Volkov Wins (+170) at Betonline
Aleksander Rakic vs Azamat Murzakanov Odds – Light Heavyweight
- Age: Aleksander Rakic (33) vs Azamat Murzakanov (36)
- Record: Aleksander Rakic (14-5) vs Azamat Murzakanov (15-0)
- Last 5: Aleksander Rakic 2-3 / Azamat Murzakanov 5-0
- Moneyline: Aleksander Rakic (-105) vs Azamat Murzakanov (-115)
- Round Total: 2.5 Total Rounds – Over (-130) / Under (+110)
- Most Likely Method Of Victory: Azamat Murzakanov By KO/TKO (+165)
Aleksander Rakic vs Azamat Murzakanov Prediction: Aleksander Rakic Wins (-105) at Betonline
Nasarat Haqparast vs Quillan Salkilld Odds – Lightweight
- Age: Nasarat Haqparast (30) vs Quillan Salkilld (25)
- Record: Nasarat Haqparast (18-5) vs Quillan Salkilld (9-1)
- Last 5: Nasarat Haqparast 5-0 / Quillan Salkilld 5-0
- Moneyline: Nasarat Haqparast (-112) vs Quillan Salkilld (-108)
- Round Total: 2.5 Total Rounds – Over (-200) / Under (+174)
- Most Likely Method Of Victory: Quillan Salkilld By Points (+185)
Nasarat Haqparast vs Quillan Salkilld Prediction: Quillan Salkilld Wins () at Betonline
Ikram Aliskerov vs Jun Yong Park Odds – Middleweight
- Age: Ikram Aliskerov (32) vs Jun Yong Park (34)
- Record: Ikram Aliskerov (16-2) vs Jun Yong Park (19-6)
- Last 5: Ikram Aliskerov 4-1 / Jun Yong Park 4-1
- Moneyline: Ikram Aliskerov (-240) vs Jun Yong Park (+205)
- Round Total: 2.5 Total Rounds – Over (+100) / Under (-120)
- Most Likely Method Of Victory: Ikram Aliskerov By Points (+190)
Ikram Aliskerov vs Jun Yong Park Prediction: Ikram Aliskerov Wins (-240) at Betonline
Mateusz Rebecki vs Ludovit Klein Odds – Lightweight
- Age: Mateusz Rebecki (33) vs Ludovit Klein (30)
- Record: Mateusz Rebecki (20-3) vs Ludovit Klein (23-5)
- Last 5: Mateusz Rebecki 3-2 / Ludovit Klein 4-1
- Moneyline: Mateusz Rebecki (+128) vs Ludovit Klein (-148)
- Round Total: 2.5 Total Rounds – Over (-125) / Under (+105)
- Most Likely Method Of Victory: Ludovit Klein By Points (+200)
Mateusz Rebecki vs Ludovit Klein Prediction: Ludovit Klein Wins (-148) at Betonline
Abdul Al – Selwady vs Matheus Camilo Odds – Lightweight
- Age: Abdul Al – Selwady (30) vs Matheus Camilo (24)
- Record: Abdul Al – Selwady (15-4) vs Matheus Camilo (9-3)
- Last 5: Abdul Al – Selwady 4-1 / Matheus Camilo 4-1
- Moneyline: Abdul Al – Selwady (-117) vs Matheus Camilo (-103)
- Round Total: 1.5 Total Rounds – Over (-175) / Under (+153)
- Most Likely Method Of Victory: Abdul Al – Selwady By Points (+165)
Abdul Al – Selwady vs Matheus Camilo Prediction: Matheus Camilo Wins (-103) at Betonline
Valter Walker vs Louis Sutherland Odds – Heavyweight
- Age: Valter Walker (27) vs Louis Sutherland (31)
- Record: Valter Walker (14-1) vs Louis Sutherland (10-3)
- Last 5: Valter Walker 4-1 / Louis Sutherland 4-1
- Moneyline: Valter Walker (-325) vs Louis Sutherland (+275)
- Round Total: 1.5 Total Rounds – Over (-170) / Under (+149)
- Most Likely Method Of Victory: Valter Walker By Submission (+125)
Valter Walker vs Louis Sutherland Prediction: Under 1.5 Total Rounds (+149) at Betonline
Jose Delgado vs Nathanial Wood Odds – Featherweight
- Age: Jose Delgado (27) vs Nathanial Wood (32)
- Record: Jose Delgado (10-1) vs Nathanial Wood (21-6)
- Last 5: Jose Delgado 5-0 / Nathanial Wood 4-1
- Moneyline: Jose Delgado (-140) vs Nathanial Wood (+120)
- Round Total: 2.5 Total Rounds – Over (-115) / Under (-105)
- Most Likely Method Of Victory: Nathanial Wood By Points (+210)
Jose Delgado vs Nathanial Wood Prediction: Jose Delgado Wins (-140) at Betonline
Chris Barnett vs Hamdy Abdelwahab Odds – Heavyweight
- Age: Chris Barnett (39) vs Hamdy Abdelwahab (32)
- Record: Chris Barnett (23-9) vs Hamdy Abdelwahab (4-1)
- Last 5: Chris Barnett 2-3 / Hamdy Abdelwahab 3-1-1
- Moneyline: Chris Barnett (+350) vs Hamdy Abdelwahab (-450)
- Round Total: 1.5 Total Rounds – Over (-170) / Under (+149)
- Most Likely Method Of Victory: Hamdy Abdelwahab By KO/TKO (+120)
Chris Barnett vs Hamdy Abdelwahab Prediction: Hamdy Abdelwahab Wins (-450) at Betonline
Azat Maksum vs Mitch Raposo Odds – Flyweight
- Age: Azat Maksum (30) vs Mitch Raposo (27)
- Record: Azat Maksum (15-2) vs Mitch Raposo (9-3)
- Last 5: Azat Maksum 3-2 / Mitch Raposo 3-2
- Moneyline: Azat Maksum (-400) vs Mitch Raposo (+330)
- Round Total: 2.5 Total Rounds – Over (-171) / Under (+150)
- Most Likely Method Of Victory: Azat Maksum By Points (+110)
Azat Maksum vs Mitch Raposo Prediction: Under 2.5 Total Rounds (+150) at Betonline
Jaqueline Amorim vs Mizuki Inoue Odds – Strawweight
- Age: Jaqueline Amorim (30) vs Mizuki Inoue (31)
- Record: Jaqueline Amorim (10-1) vs Mizuki Inoue (15-6)
- Last 5: Jaqueline Amorim 4-1 / Mizuki Inoue 3-2
- Moneyline: Jaqueline Amorim (-450) vs Mizuki Inoue (+350)
- Round Total: 2.5 Total Rounds – Over (+110) / Under (-130)
- Most Likely Method Of Victory: Jaqueline Amorim By Submission (+130)
Jaqueline Amorim vs Mizuki Inoue Prediction: Over 2.5 Total Rounds (+110) at Betonline
UFC 321 Schedule & FAQ:
When is UFC 321?
- UFC 321 will take place Saturday, October 25th, 2025.
Where is UFC 321?
- UFC 321 will go down live at Etihad Arena in Abu – Dhabi, U.A.E.
What time does UFC 321 start?
- UFC 321 Early Preliminary Card Start time: 10:00 a.m. ET
- UFC 321 Preliminary Card start time: 12:00 p.m. ET
- UFC 321 Main Card start time: 3 p.m. ET
How to Watch UFC 321?
- UFC 321 Early Preliminary Card Coverage: ESPN & ESPN+
- UFC 321 Preliminary Card Coverage: ESPN & ESPN+
- UFC 321 Main Card Coverage: ESPN+
How to Bet on UFC 321?
- Most international and domestic sportsbooks will carry odds for a fight card of this caliber but click here for some sites and applications us bettors here at Betting News recommend for a great UFC betting experience.