The Hamilton Tiger-Cats and Saskatchewan Roughriders were not among the leading Grey Cup favorites in the preseason, but halfway through the 2025 CFL calendar, these are the two teams setting the standard in the league. Which contender will strike the biggest blows in this afternoon’s Tiger-Cats vs. Roughriders rumble in Regina?
Saskatchewan (7-1) currently holds the best record in the CFL, with their ledger including a 28-23 win at Hamilton (6-3) in Week 2. Will they sweep the regular season series? Read on for our Tiger-Cats vs. Roughriders prediction and expert picks and see which top U.S. sportsbooks offer the best betting value for the top matchup in CFL Week 11.
Hamilton Tiger-Cats vs. Saskatchewan Roughriders Odds
| Team | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Hamilton Tiger-Cats | +3.5 (-120) | +153 | Over 53 (-115) |
| Saskatchewan Roughriders | -3.5 (+100) | -175 | Under 53 (-105) |
Tiger-Cats vs. Roughriders Prediction and Picks
The Week 2 matchup between the Ti-Cats and Riders at Tim Hortons Field was an even contest, and both teams had a decent day offensively. In the end, the visitors left Hamilton victorious after making KeeSean Johnson’s go-ahead touchdown in the fourth quarter stand up.
That loss dropped Hamilton to 0-2, and it looked like another losing campaign could be ahead.
However, that was the last loss for the Tiger-Cats until their six-game win streak agonizingly ended last week in overtime to the BC Lions. Receiver Tim White coughed up the ball on the second play of Hamilton’s overtime possession, opening the door for the Lions to win with a field goal on their OT possession.
White’s fumble was certainly very costly, but it wasn’t the biggest culprit. That would be the defense, which has bent quite a bit in recent weeks but broke against BC. That unit allowed 527 yards, offsetting another 300-yard game by Bo Levi Mitchell, and couldn’t preserve a 35-31 lead in the final minutes of the fourth quarter.
Ultimately, Hamilton’s defensive deficiencies could make or break their chances to hoist the Grey Cup for the first time since 1999. It will also likely be what makes the difference in today’s Tiger-Cats vs. Roughriders matchup.
Mitchell should have another productive day even against one of the league’s better defenses, but Riders QB Trevor Harris, who entered Week 11 as the league’s leader in QB rating and has completed 75.2% of his passes, should have a field day at home.
Take the Riders to cover and improve to 4-1 at home, and take the over in what should be a fairly high scoring game.
Tiger-Cats vs. Roughriders Prediction: Roughriders to win
Tiger-Cats vs. Roughriders Picks: 1) Roughriders -3.5 (+100 at BetOnline) 2) Tiger-Cats/Roughriders over 53 (-115 at Everygame) 3) Bo Levi Mitchell over 320.5 passing yards (-110 at Bovada)
Other CFL Week 11 Betting Information
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